Psychedelic and ketamine research trials in Switzerland
Data as of 11 October 2026. Source: ClinicalTrials.gov records held by PsychoactiveMap, refreshed from a reviewed snapshot.
70 registered studies are counted in Switzerland. By compound: 21 psilocybin, 27 MDMA, 32 LSD, 10 DMT, 2 5-MeO-DMT, 2 ayahuasca, 5 ketamine and 2 mescaline. By registry status: 12 recruiting, 3 not yet recruiting, 1 enrolling by invitation, 1 active, not recruiting, 52 completed and 1 terminated. By phase: 12 early phase 1, 32 phase 1, 12 phase 2, 12 not applicable and 2 not reported. Reported start years run from 2001 (earliest) to 2026 (latest). Studies are linked to 10 institutions.
Country is taken from the research site linked to each registry record. A study counts once, and a study tagged with more than one compound is counted under each compound. Ketamine studies are counted only when PsychoactiveMap classifies them as psychiatric research; anaesthesia, sedation and pain studies are left out.
Educational information, not medical advice. A registry listing is not evidence of safety, benefit or results, and it is not a recommendation. PsychoactiveMap does not recruit, screen or refer participants. Status and other details are copied from the registry and can be out of date, so check the registry record and speak to a qualified health professional before any decision. Read the full disclaimer.
Recruiting now
15 of the 70 counted studies are listed in the registry as recruiting (12) or not yet recruiting (3), newest start first. Status is reported by study teams and can be out of date. PsychoactiveMap does not recruit, screen or refer anyone; eligibility and contact details are on each registry record.
| Title as registered | Registry ID | Status | Phase | Start | Institution and city |
|---|---|---|---|---|---|
| Circulating Oxytocin Changes in Response to MDMA vs. Placebo in Adult Patients With Autism Spectrum Disorder and Matched Healthy Controls | NCT07555132 | Not yet recruiting | Not applicable | 2026-06-01 | University Hospital, Basel, Switzerland, Basel |
| Acute Effects of Intravenous 5-MeO-DMT in Healthy Participants | NCT07444788 | Recruiting | Phase 1 | 2026-03-31 | University Hospital, Basel, Switzerland, Basel |
| Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants | NCT07494214 | Recruiting | Phase 1 | 2026-03-09 | University Hospital, Basel, Switzerland, Basel |
| Pharmacokinetics of Didehydro-LSD (DDH-LSD) Compared With LSD | NCT07309471 | Recruiting | Not applicable | 2026-01-01 | University Hospital, Basel, Switzerland, Basel |
| Microdosing LSD in Women With Premenstrual Disorders | NCT07189299 | Not yet recruiting | Not applicable | 2025-10-01 | University Hospital, Basel, Switzerland, Basel |
| Antidepressant Response of DMT Masked With Propofol | NCT06927076 | Recruiting | Not applicable | 2025-08-05 | University Hospital, Basel, Switzerland, Basel |
| Ketamine and Neurofeedback as Combined Therapeutic Interventions to Target Glutamatergic Neurotransmission in Alcohol Use Disorder | NCT06969937 | Recruiting | Phase 2 | 2025-06-01 | Psychiatric University Hospital, Zurich, Zurich |
| Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of Consciousness | NCT06796361 | Recruiting | Phase 1 | 2025-04-21 | University Hospital, Basel, Switzerland, Basel |
| Effects of Intranasal Ketamine on Depression and Anxiety in Palliative Care Cancer Patients | NCT06665568 | Not yet recruiting | Early Phase 1 | 2025-04-01 | University of Zurich, Zurich |
| Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy Participants | NCT06899334 | Recruiting | Phase 1 | 2025-04-01 | University Hospital, Basel, Switzerland, Basel |
| Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy Controls | NCT06789705 | Recruiting | Not applicable | 2025-01-27 | University Hospital, Basel, Switzerland, Basel |
| Lysergic Acid Diethylamide (LSD) in Palliative Care | NCT05883540 | Recruiting | Phase 2 | 2024-06-09 | University Hospital, Basel, Switzerland, Basel |
| LSD Treatment for Persons With Alcohol Use Disorder | NCT05474989 | Recruiting | Phase 2 | 2024-06-01 | University Hospital, Basel, Switzerland, Basel |
| Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction | NCT06125054 | Recruiting | Phase 2 | 2024-02-05 | Psychiatric University Hospital, Zurich, Zurich |
| Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headache | NCT03781128 | Recruiting | Phase 2 | 2019-01-02 | University Hospital, Basel, Switzerland, Basel |
At a glance
- 70 registered studies are counted on this page.
By compound
| Compound hub | Studies |
|---|---|
| Psilocybin | 21 |
| MDMA | 27 |
| LSD | 32 |
| DMT | 10 |
| 5-MeO-DMT | 2 |
| Ayahuasca | 2 |
| Ketamine | 5 |
| Mescaline | 2 |
By registry status
| Status | Studies | Share |
|---|---|---|
| Recruiting | 12 | 17% |
| Not yet recruiting | 3 | 4% |
| Enrolling by invitation | 1 | 1% |
| Active, not recruiting | 1 | 1% |
| Completed | 52 | 74% |
| Terminated | 1 | 1% |
By phase
| Phase | Studies | Share |
|---|---|---|
| Early Phase 1 | 12 | 17% |
| Phase 1 | 32 | 46% |
| Phase 2 | 12 | 17% |
| Not applicable | 12 | 17% |
| Not reported | 2 | 3% |
When studies started
| Start year | Studies |
|---|---|
| 2024 to 2026 | 22 |
| 2020 to 2023 | 21 |
| 2015 to 2019 | 11 |
| 2010 to 2014 | 10 |
| Before 2010 | 6 |
All counted studies
All 70 counted studies, newest start first. The order is not a ranking and says nothing about quality. Titles are quoted from the registry. Each ID links to its own ClinicalTrials.gov record, which has the eligibility criteria and contacts.
| Title as registered | Registry ID | Status | Phase | Start | Institution and city |
|---|---|---|---|---|---|
| Circulating Oxytocin Changes in Response to MDMA vs. Placebo in Adult Patients With Autism Spectrum Disorder and Matched Healthy Controls | NCT07555132 | Not yet recruiting | Not applicable | 2026-06-01 | University Hospital, Basel, Switzerland, Basel |
| Acute Effects of Intravenous 5-MeO-DMT in Healthy Participants | NCT07444788 | Recruiting | Phase 1 | 2026-03-31 | University Hospital, Basel, Switzerland, Basel |
| Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants | NCT07494214 | Recruiting | Phase 1 | 2026-03-09 | University Hospital, Basel, Switzerland, Basel |
| Pharmacokinetics of Didehydro-LSD (DDH-LSD) Compared With LSD | NCT07309471 | Recruiting | Not applicable | 2026-01-01 | University Hospital, Basel, Switzerland, Basel |
| Microdosing LSD in Women With Premenstrual Disorders | NCT07189299 | Not yet recruiting | Not applicable | 2025-10-01 | University Hospital, Basel, Switzerland, Basel |
| Antidepressant Response of DMT Masked With Propofol | NCT06927076 | Recruiting | Not applicable | 2025-08-05 | University Hospital, Basel, Switzerland, Basel |
| Comparative Acute Effects of R-MDMA and S-MDMA in Healthy Participants | NCT06905652 | Completed | Phase 1 | 2025-07-29 | University Hospital, Basel, Switzerland, Basel |
| Ketamine and Neurofeedback as Combined Therapeutic Interventions to Target Glutamatergic Neurotransmission in Alcohol Use Disorder | NCT06969937 | Recruiting | Phase 2 | 2025-06-01 | Psychiatric University Hospital, Zurich, Zurich |
| Role of the Serotonin 2A Receptor in Psilocybin-induced Altered States of Consciousness | NCT06796361 | Recruiting | Phase 1 | 2025-04-21 | University Hospital, Basel, Switzerland, Basel |
| Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy Subjects | NCT06884514 | Completed | Phase 1 | 2025-04-03 | University Hospital, Basel, Switzerland, Basel |
| Effects of Intranasal Ketamine on Depression and Anxiety in Palliative Care Cancer Patients | NCT06665568 | Not yet recruiting | Early Phase 1 | 2025-04-01 | University of Zurich, Zurich |
| Direct Comparison of Altered States of Consciousness Induced by LSD, Psilocybin, and DMT in Healthy Participants | NCT06899334 | Recruiting | Phase 1 | 2025-04-01 | University Hospital, Basel, Switzerland, Basel |
| Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy Controls | NCT06789705 | Recruiting | Not applicable | 2025-01-27 | University Hospital, Basel, Switzerland, Basel |
| Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants | NCT06180759 | Completed | Phase 1 | 2025-01-23 | University Hospital, Basel, Switzerland, Basel |
| Salivary Oxytocin as a Biomarker in Psychedelic Assisted Psychotherapy | NCT06557239 | Completed | Not reported | 2024-08-05 | University of Geneva, Switzerland, Geneva |
| Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study) | NCT05695495 | Completed | Phase 1 | 2024-06-12 | University Hospital, Basel, Switzerland, Basel |
| Lysergic Acid Diethylamide (LSD) in Palliative Care | NCT05883540 | Recruiting | Phase 2 | 2024-06-09 | University Hospital, Basel, Switzerland, Basel |
| LSD Treatment for Persons With Alcohol Use Disorder | NCT05474989 | Recruiting | Phase 2 | 2024-06-01 | University Hospital, Basel, Switzerland, Basel |
| LSD-Perceptual-Choice-Study | NCT05976698 | Completed | Not applicable | 2024-02-26 | University Hospital, Basel, Switzerland, Basel |
| Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction | NCT06125054 | Recruiting | Phase 2 | 2024-02-05 | Psychiatric University Hospital, Zurich, Zurich |
| Effect of Ketanserin, Olanzapine, and Lorazepam After LSD Administration on the Acute Response to LSD in Healthy Subjects | NCT05964647 | Completed | Phase 1 | 2024-02-01 | University Hospital, Basel, Switzerland, Basel |
| Molecular Imaging Study of Harmine/DMT: a Basic Research Approach | NCT06252506 | Completed | Phase 1 | 2024-01-22 | Insel Gruppe AG, University Hospital Bern, Bern |
| Acute Effects of 3,4-methylenedioxymethamphetamine (MDMA) With and Without a Booster Dose | NCT05809271 | Completed | Phase 1 | 2023-11-17 | University Hospital, Basel, Switzerland, Basel |
| Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans | NCT06081179 | Completed | Phase 1 | 2023-10-24 | University of Zurich, Zurich |
| Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects | NCT05523401 | Completed | Phase 1 | 2023-08-16 | University Hospital, Basel, Switzerland, Basel |
| Mindfulness and Psychedelics | NCT05780216 | Completed | Early Phase 1 | 2023-02-20 | Psychiatric University Hospital, Zurich, Zurich |
| Acute Dose-dependent Effects of DMT in Healthy Subjects | NCT05384678 | Completed | Phase 1 | 2022-11-15 | University Hospital, Basel, Switzerland, Basel |
| The Role of Personal Experience for the Therapeutic Attitude in the Context of Substance-assisted Therapy Training | NCT05570708 | Enrolling by invitation | Not applicable | 2022-10-25 | University Hospital, Basel, Switzerland, Basel |
| Effects of SERT Inhibition on the Subjective Response to LSD in Healthy Subjects | NCT05175430 | Completed | Phase 1 | 2022-10-24 | University Hospital, Basel, Switzerland, Basel |
| Acute Effects of R- and S-MDMA in Healthy Subjects | NCT05277636 | Completed | Phase 1 | 2022-10-01 | University Hospital, Basel, Switzerland, Basel |
| Effects of LSD on Neuroplasticity in Healthy Subjects | NCT05177419 | Completed | Phase 1 | 2022-05-02 | University of Fribourg, Fribourg |
| LSD Base and LSD Tartrate Bioequivalence and Bioavailability in Healthy Subjects | NCT04865653 | Completed | Phase 1 | 2022-03-17 | University Hospital, Basel, Switzerland, Basel |
| Effects of MDMA-like Substances in Healthy Subjects | NCT04847206 | Completed | Phase 1 | 2021-12-01 | University Hospital, Basel, Switzerland, Basel |
| Role of the Serotonin 5-HT2A Receptor in Mescaline-induced Altered States of Consciousness | NCT04849013 | Completed | Phase 1 | 2021-08-11 | University Hospital, Basel, Switzerland, Basel |
| Effects of Dimethyltryptamine in Healthy Subjects | NCT04353024 | Completed | Phase 1 | 2021-06-18 | University Hospital, Basel, Switzerland, Basel |
| Circulating Oxytocin Changes in Response to the Oxytocin System Stimulator MDMA in Patients With Diabetes Insipidus and Healthy Controls | NCT04648137 | Completed | Not applicable | 2021-02-05 | University Hospital, Basel, Switzerland, Basel |
| Effects of MDMA Co-administration on the Response to LSD in Healthy Subjects | NCT04516902 | Completed | Phase 1 | 2021-01-01 | University Hospital, Basel, Switzerland, Basel |
| Neurodynamics of Prosocial Emotional Processing Following Serotonergic Stimulation With N,N-Dimethyltryptamine (DMT) and Harmine in Healthy Subjects | NCT04716335 | Completed | Early Phase 1 | 2020-12-01 | Psychiatric University Hospital, Zurich, Zurich |
| Effect of Ketanserin After LSD Administration | NCT04558294 | Completed | Phase 1 | 2020-10-16 | University Hospital, Basel, Switzerland, Basel |
| Characterization of Altered Waking States of Consciousness in Healthy Humans | NCT03853577 | Completed | Not applicable | 2020-07-08 | University of Zurich, Zurich |
| Clinical and Mechanistic Effects of Psilocybin in Alcohol Addicted Patients | NCT04141501 | Completed | Phase 2 | 2020-06-08 | University of Zurich, Zurich |
| Retrospective Observational Study of Intensity Effects in Psychedelic-assisted Treatment | NCT07164287 | Active, not recruiting | Not reported | 2020-06-01 | University Hospital, Geneva, Geneva |
| Comparative Acute Effects of LSD, Psilocybin and Mescaline | NCT04227756 | Completed | Phase 1 | 2020-05-19 | University Hospital, Basel, Switzerland, Basel |
| LSD Therapy for Persons Suffering From Major Depression | NCT03866252 | Completed | Phase 2 | 2019-11-01 | University Hospital, Basel, Switzerland, Basel |
| Effect of Methylenedioxymethamphetamine (MDMA) (Serotonin Release) on Fear Extinction | NCT03527316 | Completed | Early Phase 1 | 2019-10-18 | University Hospital, Basel, Switzerland, Basel |
| Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy Subjects | NCT03912974 | Completed | Phase 1 | 2019-07-04 | University Hospital, Basel, Switzerland, Basel |
| Direct Comparison of Altered States of Consciousness Induced by LSD and Psilocybin | NCT03604744 | Completed | Early Phase 1 | 2019-03-27 | University Hospital, Basel, Switzerland, Basel |
| Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of Concept | NCT03715127 | Completed | Phase 2 | 2019-03-11 | University of Zurich, Zurich |
| Lysergic Acid Diethylamide (LSD) as Treatment for Cluster Headache | NCT03781128 | Recruiting | Phase 2 | 2019-01-02 | University Hospital, Basel, Switzerland, Basel |
| Role of the Serotonin 5-HT2A Receptor in LSD-induced Altered States of Consciousness (LDR-Study) | NCT03321136 | Completed | Early Phase 1 | 2017-11-28 | University Hospital, Basel, Switzerland, Basel |
| LSD Treatment in Persons Suffering From Anxiety Symptoms in Severe Somatic Diseases or in Psychiatric Anxiety Disorders | NCT03153579 | Completed | Phase 2 | 2017-06-23 | University Hospital, Basel, Switzerland, Basel |
| Role of Dopamine, Serotonin and 5-HT2A Receptors in Emotion Processing | NCT03019822 | Completed | Early Phase 1 | 2017-02-01 | University Hospital, Basel, Switzerland, Basel |
| The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers | NCT02451072 | Completed | Not applicable | 2015-03-01 | Psychiatric University Hospital, Zurich, Zurich |
| A Multimodal Neuroimaging Study of Brain Activation Patterns Under Ketamine | NCT03609190 | Completed | Early Phase 1 | 2015-01-01 | Psychiatric University Hospital, Zurich, Zurich |
| Neuronal Correlates of Altered States of Consciousness | NCT02308969 | Completed | Early Phase 1 | 2014-12-01 | University Hospital, Basel, Switzerland, Basel |
| Effects of Methylphenidate, Modafinil, and MDMA on Emotion-processing in Humans: A Pharmaco-fMRI Study | NCT01951508 | Completed | Early Phase 1 | 2013-10-01 | University Hospital, Basel, Switzerland, Basel |
| Psychological, Physiological, Endocrine, and Pharmacokinetic Effects of LSD in a Controlled Study | NCT01878942 | Completed | Early Phase 1 | 2013-06-01 | University Hospital, Basel, Switzerland, Basel |
| Influence of Bupropion on the Effects of MDMA | NCT01771874 | Completed | Phase 1 | 2013-01-01 | University Hospital, Basel, Switzerland, Basel |
| Effects of MDMA and Methylphenidate on Social Cognition | NCT01616407 | Completed | Early Phase 1 | 2012-08-01 | University Hospital, Basel, Switzerland, Basel |
| Emotional Effects of Methylphenidate and MDMA in Healthy Subjects | NCT01465685 | Completed | Phase 1 | 2011-12-01 | University Hospital, Basel, Switzerland, Basel |
| Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA) | NCT01386177 | Completed | Phase 1 | 2011-07-01 | University Hospital, Basel, Switzerland, Basel |
| Pharmacological Interaction Between Carvedilol and Methylenedioxymethamphetamine (MDMA) | NCT01270672 | Completed | Not applicable | 2011-01-01 | University Hospital, Basel, Switzerland, Basel |
| Pharmacological Interaction Between Clonidine and Methylenedioxymethamphetamine (MDMA) | NCT01136278 | Completed | Phase 1 | 2010-07-01 | University Hospital, Basel, Switzerland, Basel |
| Study of Depression-Ketamine-Brain Function | NCT01135758 | Terminated | Phase 2 | 2010-06-01 | University Hospital, Geneva, Geneva |
| Interaction Between Duloxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy) | NCT00990067 | Completed | Phase 1 | 2009-11-01 | University Hospital, Basel, Switzerland, Basel |
| Interaction Between Reboxetine and 3,4-Methylenedioxymethamphetamine: Pharmacodynamics (PD) and Pharmacokinetics (PK) | NCT00886886 | Completed | Phase 1 | 2009-04-01 | University Hospital, Basel, Switzerland, Basel |
| Lysergic Acid Diethylamide (LSD)-Assisted Psychotherapy in People With Illness-related Anxiety | NCT00920387 | Completed | Phase 2 | 2008-02-01 | Multidisciplinary Association for Psychedelic Studies, Solothurn |
| Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress Disorder | NCT00353938 | Completed | Phase 2 | 2006-09-13 | Lykos Therapeutics, Biberist |
| Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging | NCT01296802 | Completed | Not applicable | 2006-04-01 | University of Zurich, Zurich |
| Pharmacological Interaction Between Pindolol and MDMA (3,4-Methylenedioxymethamphetamine) | NCT00895804 | Completed | Phase 1 | 2001-06-01 | University Hospital, Basel, Switzerland, Zurich |
About this data
Compound tags come from automated matching of the registry search term and have not been checked record by record. Counts are of registered studies, not of people, results or approvals. A registry listing is not evidence of safety, benefit or results.
Substance hubs for these compounds
Psilocybin | MDMA | LSD | DMT | 5-MeO-DMT | Ayahuasca | Ketamine
Institution hubs in this country
Institutions in this country with at least 3 counted studies. The number is that institution's own count of studies, which can include studies not shown above if the registry lists them under another country.
- University Hospital, Basel, Switzerland: 50 studies
- University of Zurich: 7 studies
- Psychiatric University Hospital, Zurich: 6 studies
Condition hubs
Condition hubs that include studies counted in this country, with the number of those studies. Conditions are matched by keyword on registered titles, so one study can appear under more than one condition.
| Condition hub | Studies in this country |
|---|---|
| Depression | 8 |
| Anxiety | 6 |
| Alcohol use disorder | 3 |
| Cancer and end-of-life distress | 2 |
| Post-traumatic stress disorder | 2 |
| Headache and migraine | 1 |
| Cocaine and methamphetamine use | 1 |
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