PsychoactiveMap

Psychedelic and ketamine research trials in Canada

Data as of 11 October 2026. Source: ClinicalTrials.gov records held by PsychoactiveMap, refreshed from a reviewed snapshot.

79 registered studies are counted in Canada. By compound: 39 psilocybin, 4 MDMA, 1 LSD and 36 ketamine. By registry status: 23 recruiting, 8 not yet recruiting, 1 enrolling by invitation, 9 active, not recruiting, 20 completed, 4 terminated, 2 suspended, 2 withdrawn and 10 status not reported. By phase: 1 early phase 1, 11 phase 1, 42 phase 2, 6 phase 3, 4 phase 4, 8 not applicable and 7 not reported. Reported start years run from 2013 (earliest) to 2026 (latest). Studies are linked to 37 institutions.

Country is taken from the research site linked to each registry record. A study counts once, and a study tagged with more than one compound is counted under each compound. Ketamine studies are counted only when PsychoactiveMap classifies them as psychiatric research; anaesthesia, sedation and pain studies are left out.

Educational information, not medical advice. A registry listing is not evidence of safety, benefit or results, and it is not a recommendation. PsychoactiveMap does not recruit, screen or refer participants. Status and other details are copied from the registry and can be out of date, so check the registry record and speak to a qualified health professional before any decision. Read the full disclaimer.

Recruiting now

31 of the 79 counted studies are listed in the registry as recruiting (23) or not yet recruiting (8), newest start first. Status is reported by study teams and can be out of date. PsychoactiveMap does not recruit, screen or refer anyone; eligibility and contact details are on each registry record.

Title as registeredRegistry IDStatusPhaseStartInstitution and city
MB-PAT for Demoralization in Advanced Cancer ('PAT-MIND') TrialNCT07791901Not yet recruitingPhase 22026-10-30University of Calgary, Calgary
Oral and Sublingual KetamineNCT07683988Not yet recruitingPhase 12026-10-01Western University, Canada, London
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled TrialNCT07820033Not yet recruitingPhase 22026-09-14University Health Network, Toronto, Toronto
Behavioural Activation Therapy and Ketamine for Treatment-Resistant DepressionNCT07801703Not yet recruitingPhase 22026-09-01The Royal's Institute of Mental Health Research, Ottawa
Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner ViolenceNCT06885996Not yet recruitingPhase 22026-08-01University of Calgary, Calgary
Intra-Sessional Autonomic Arc Detection in Ketamine-Assisted Therapy for PTSD: A Signal Characterisation Pilot StudyNCT07614581Not yet recruitingNot reported2026-07-15Dr. Adriaan van der Wart Medical Corp., Ganges
Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)NCT07569198RecruitingPhase 22026-06-01University Health Network, Toronto, Toronto
InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpressionNCT06781697RecruitingPhase 32026-05-01Sunnybrook Health Sciences Centre, Toronto
Understanding Music and Mindfulness Preferences in Psilocybin-Assisted PsychotherapyNCT07373535Not yet recruitingPhase 22026-05-01Sir Mortimer B. Davis - Jewish General Hospital, Montreal
Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant DepressionNCT07211438RecruitingPhase 22026-04-01Centre for Addiction and Mental Health, Toronto
Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use DisorderNCT07405606Not yet recruitingPhase 22026-03-01Centre for Addiction and Mental Health, Toronto
Subjective Experience Following PsilocybinNCT06768944RecruitingPhase 22026-02-01University of Calgary, Calgary
Psilocybin Microdose for Psychological and Existential Distress in Palliative Care (PSYCHED-PAL-RCT)NCT07063862RecruitingPhase 32026-01-01Bruyère Health Research Institute., Brampton
Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid MedicationNCT05585229RecruitingPhase 22025-10-27University of British Columbia, Kelowna
Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II DisorderNCT06943573RecruitingPhase 32025-10-01University of British Columbia, Vancouver
Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSDNCT07009158RecruitingPhase 12025-10-01Queen's University, Kingston
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Caregivers of Patients With Advanced CancerNCT07048743RecruitingPhase 22025-07-02University Health Network, Toronto, Toronto
Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted TherapyNCT06615908RecruitingPhase 12025-05-27University of Calgary, Calgary
Safety, Tolerability, and Preliminary Efficacy of Psilocybin Oral Solution in Adults With Generalized Anxiety DisorderNCT06969170RecruitingPhase 22025-05-06Queen's University, Kingston
ACT_for Alcohol Use Disorder and DepressionNCT06620276RecruitingNot applicable2025-05-01Centre hospitalier de l'Université de Montréal (CHUM), Montreal
Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)NCT06512220RecruitingPhase 22025-04-21Centre for Addiction and Mental Health, Toronto
Understanding and Treating Suicidal Ideation With KetamineNCT06891300RecruitingPhase 22025-04-08The Royal's Institute of Mental Health Research, Ottawa
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)NCT06518720RecruitingPhase 22025-04-01Centre for Addiction and Mental Health, Toronto
A Randomized Neuroimaging Trial of Psilocybin in DepressionNCT06072898RecruitingPhase 22025-03-25Sunnybrook Health Sciences Centre, Toronto
Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAINNCT06731335RecruitingPhase 22025-03-05Unity Health Toronto, Toronto
Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage CancerNCT06818994RecruitingPhase 12025-03-01Queen's University, Kingston
MDMA-Assisted CBCT for PTSD vs CBCT RCTNCT06044675RecruitingPhase 22024-11-15Remedy, Toronto
Psilocybin-Assisted Psychotherapy for Alcohol Use DisorderNCT05995769RecruitingPhase 22024-03-20University of Calgary, Calgary
IV Ketamine Vs. in Esketamine for MDD TRDNCT06488586RecruitingNot reported2023-03-20Queen's University, Kingston
Ketamine Enhances Analgesia and Mood in Chronic Pain PatientsNCT05985811RecruitingNot reported2018-02-02Salem Anaesthesia Pain Clinic, Surrey
ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant DepressionNCT03272698RecruitingPhase 42017-09-01University of Saskatchewan, Saskatoon

At a glance

By compound

Compound hubStudies
Psilocybin39
MDMA4
LSD1
Ketamine36

By registry status

StatusStudiesShare
Recruiting2329%
Not yet recruiting810%
Enrolling by invitation11%
Active, not recruiting911%
Completed2025%
Terminated45%
Suspended23%
Withdrawn23%
Status not reported1013%

By phase

PhaseStudiesShare
Early Phase 111%
Phase 11114%
Phase 24253%
Phase 368%
Phase 445%
Not applicable810%
Not reported79%

When studies started

Start yearStudies
2024 to 202643
2020 to 202324
2015 to 201910
2010 to 20142

All counted studies

All 79 counted studies, newest start first. The order is not a ranking and says nothing about quality. Titles are quoted from the registry. Each ID links to its own ClinicalTrials.gov record, which has the eligibility criteria and contacts.

Title as registeredRegistry IDStatusPhaseStartInstitution and city
MB-PAT for Demoralization in Advanced Cancer ('PAT-MIND') TrialNCT07791901Not yet recruitingPhase 22026-10-30University of Calgary, Calgary
Oral and Sublingual KetamineNCT07683988Not yet recruitingPhase 12026-10-01Western University, Canada, London
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer: A Randomized Controlled TrialNCT07820033Not yet recruitingPhase 22026-09-14University Health Network, Toronto, Toronto
Behavioural Activation Therapy and Ketamine for Treatment-Resistant DepressionNCT07801703Not yet recruitingPhase 22026-09-01The Royal's Institute of Mental Health Research, Ottawa
Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner ViolenceNCT06885996Not yet recruitingPhase 22026-08-01University of Calgary, Calgary
Intra-Sessional Autonomic Arc Detection in Ketamine-Assisted Therapy for PTSD: A Signal Characterisation Pilot StudyNCT07614581Not yet recruitingNot reported2026-07-15Dr. Adriaan van der Wart Medical Corp., Ganges
Psilocybin-Assisted Group Integration Psychotherapy for Treatment-Resistant DepressionNCT07737990Enrolling by invitationNot applicable2026-07-01University Health Network, Toronto, Toronto
Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT)NCT07569198RecruitingPhase 22026-06-01University Health Network, Toronto, Toronto
InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpressionNCT06781697RecruitingPhase 32026-05-01Sunnybrook Health Sciences Centre, Toronto
Understanding Music and Mindfulness Preferences in Psilocybin-Assisted PsychotherapyNCT07373535Not yet recruitingPhase 22026-05-01Sir Mortimer B. Davis - Jewish General Hospital, Montreal
Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant DepressionNCT07211438RecruitingPhase 22026-04-01Centre for Addiction and Mental Health, Toronto
Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSDNCT06386003Active, not recruitingPhase 22026-03-01Unity Health Toronto, Toronto
Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use DisorderNCT07405606Not yet recruitingPhase 22026-03-01Centre for Addiction and Mental Health, Toronto
Subjective Experience Following PsilocybinNCT06768944RecruitingPhase 22026-02-01University of Calgary, Calgary
Psilocybin Microdose for Psychological and Existential Distress in Palliative Care (PSYCHED-PAL-RCT)NCT07063862RecruitingPhase 32026-01-01Bruyère Health Research Institute., Brampton
Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid MedicationNCT05585229RecruitingPhase 22025-10-27University of British Columbia, Kelowna
Psilocybin-Assisted Therapy for Treatment-Resistant Depression in Bipolar II DisorderNCT06943573RecruitingPhase 32025-10-01University of British Columbia, Vancouver
Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSDNCT07009158RecruitingPhase 12025-10-01Queen's University, Kingston
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Caregivers of Patients With Advanced CancerNCT07048743RecruitingPhase 22025-07-02University Health Network, Toronto, Toronto
Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted TherapyNCT06615908RecruitingPhase 12025-05-27University of Calgary, Calgary
Safety, Tolerability, and Preliminary Efficacy of Psilocybin Oral Solution in Adults With Generalized Anxiety DisorderNCT06969170RecruitingPhase 22025-05-06Queen's University, Kingston
ACT_for Alcohol Use Disorder and DepressionNCT06620276RecruitingNot applicable2025-05-01Centre hospitalier de l'Université de Montréal (CHUM), Montreal
Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)NCT06512220RecruitingPhase 22025-04-21Centre for Addiction and Mental Health, Toronto
Understanding and Treating Suicidal Ideation With KetamineNCT06891300RecruitingPhase 22025-04-08The Royal's Institute of Mental Health Research, Ottawa
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)NCT06518720RecruitingPhase 22025-04-01Centre for Addiction and Mental Health, Toronto
A Randomized Neuroimaging Trial of Psilocybin in DepressionNCT06072898RecruitingPhase 22025-03-25Sunnybrook Health Sciences Centre, Toronto
Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAINNCT06731335RecruitingPhase 22025-03-05Unity Health Toronto, Toronto
Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept StudyNCT06225232Active, not recruitingPhase 22025-03-01McMaster University, Hamilton
Safety and Efficacy of Psilocybin-assisted Psychotherapy for Demoralization Syndrome in Patients Diagnosed With Advanced Stage CancerNCT06818994RecruitingPhase 12025-03-01Queen's University, Kingston
Psychedelic-assisted Group Program for First RespondersNCT06471959Status not reportedPhase 12025-01-01Empower Research Inc, Surrey
MDMA-Assisted CBCT for PTSD vs CBCT RCTNCT06044675RecruitingPhase 22024-11-15Remedy, Toronto
The Effects of Psilocybin on Shared Experience in Film ProcessingNCT06529939Status not reportedNot applicable2024-11-01Western University, Canada, London
Psilocybin for Treatment-Resistant Depression in AutismNCT06731621Active, not recruitingPhase 12024-11-01Centre for Addiction and Mental Health, Toronto
Neurobiological Effects of Psilocybin in Treatment Resistant Bipolar DepressionNCT06506019Active, not recruitingPhase 12024-10-09University Health Network, Toronto, Toronto
Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCDNCT06299319CompletedPhase 12024-09-01Centre for Addiction and Mental Health, Toronto
Behavioural Activation Therapy and Esketamine for Resistant DepressionNCT06431386TerminatedNot applicable2024-06-11The Royal's Institute of Mental Health Research, Ottawa
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced CancerNCT06416085Active, not recruitingPhase 22024-06-06University Health Network, Toronto, Toronto
Psilocybin-Assisted Psychotherapy for Alcohol Use DisorderNCT05995769RecruitingPhase 22024-03-20University of Calgary, Calgary
Psilocybin-Assisted Psychotherapy for Treatment-Resistant Depression: Comparing One Versus Two Doses of PsilocybinNCT06341426Active, not recruitingPhase 22024-02-05University Health Network, Toronto, Toronto
Predictors of Intravenous Ketamine Response in TRDNCT05625555Active, not recruitingPhase 32024-01-19Nova Scotia Health Authority, Halifax
Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal IdeationNCT06366334Status not reportedNot applicable2024-01-15Children's Hospital of Eastern Ontario, Ottawa
PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL)NCT04754061Active, not recruitingPhase 12024-01-08Ottawa Hospital Research Institute, Ottawa
i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical TrialNCT06480500Active, not recruitingPhase 22024-01-02University Health Network, Toronto, Toronto
Does Psilocybin Change Synaptic Density in Amnestic Mild Cognitive ImpairmentNCT06041152CompletedPhase 22023-11-27Centre for Addiction and Mental Health, Toronto
Microdosing Psychedelics to Improve MoodNCT05259943CompletedPhase 22023-07-15University of Toronto, Toronto
Does Psilocybin Require Psychedelic Effects to Treat Depression?NCT05710237CompletedPhase 22023-07-01Centre for Addiction and Mental Health, Toronto
Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal IdeationNCT05468840Status not reportedPhase 32023-06-01University of Ottawa, Ottawa
An Investigation of Psilocybin on Behavioural and Cognitive Symptoms of Adults With Fragile X SyndromeNCT05832255SuspendedPhase 22023-03-28Nova Mentis Life Science Corp, London
IV Ketamine Vs. in Esketamine for MDD TRDNCT06488586RecruitingNot reported2023-03-20Queen's University, Kingston
Repeated Intranasal Esketamine Plus Almond Therapy in Participants With Treatment Resistant Depressive Disorder - 3 Month Extension StudyNCT05438758WithdrawnPhase 22023-01-15Zylorion Health, Edmonton
Effect of SSRIs on Response to Psilocybin TherapyNCT05594667WithdrawnPhase 22023-01-01Cybin Therapeutics Inc., Abbotsford
Repeated Intranasal Esketamine Plus Almond Therapy in Patients With Treatment Resistant DepressionNCT05323019TerminatedPhase 22022-10-13Zylorion Health, Edmonton
Investigating the Therapeutic Effects of Psilocybin in Treatment-Resistant Post-Traumatic Stress DisorderNCT05243329Status not reportedPhase 22022-10-03Halucenex Life Sciences Inc., Windsor
Auditory MMN EEG in TRD in Response to KetamineNCT05464264Status not reportedNot reported2022-10-03Unity Health Toronto, Toronto
Maintenance Ketamine Infusions for Treatment-Resistant Bipolar DepressionNCT05339074CompletedPhase 22022-08-11University Health Network, Toronto, Toronto
Ketamine for Treatment-Resistant Bipolar DisorderNCT05004896CompletedPhase 22022-07-04University Health Network, Toronto, Toronto
Ketamine Infusion for Rapid Reduction of Suicidality in PediatricsNCT04955470TerminatedPhase 12022-06-01University of British Columbia, Vancouver
Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar DepressionNCT05177146CompletedNot applicable2022-05-04Centre for Addiction and Mental Health, Toronto
Psilocybin-Assisted Psychotherapy in Adults With Alcohol Use Disorder (AUD)NCT05646303Status not reportedPhase 22022-05-02Clairvoyant Therapeutics, Calgary
Chart Review of Patients Undergoing Ketamine Treatments for DepressionNCT07099235CompletedNot reported2022-04-01Sunnybrook Health Sciences Centre, Mississauga
Psilocybin for Treatment-Resistant DepressionNCT05029466CompletedPhase 22021-11-19Brain and Cognition Discovery Foundation, Mississauga
Intranasal Ketamine in Ultra-REsistant Depression (SURE-ECT Non Responders)NCT05137938CompletedNot applicable2021-10-25Centre for Addiction and Mental Health, Toronto
Identification of a Safe and Non-Psychedelic Dose of PsilocybinNCT07710027CompletedPhase 12021-10-19Diamond Therapeutics Inc., Toronto
A Phase 2 Open-Label Treatment Development Study of MDMA-Assisted Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder (PTSD)NCT05067244CompletedPhase 22021-10-04Remedy, Toronto
Combined Ketamine and eCBT Intervention for PTSDNCT04771767Status not reportedPhase 22021-08-01Queen's University, Kingston
Pharmacogenetics Associated With IV KetamineNCT04695405CompletedNot reported2021-01-21Brain and Cognition Discovery Foundation, Mississauga
Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in DepressionNCT04701866CompletedNot applicable2021-01-11Douglas Mental Health University Institute, Montreal
Chart Review of Patients Undergoing Ketamine InfusionsNCT04209296CompletedNot reported2019-12-03Brain and Cognition Discovery Foundation, Mississauga
Ketamine Co-induction for Patients With Major Depressive DisorderNCT03666494Status not reportedPhase 42018-12-01University of Saskatchewan, Saskatoon
Ketamine Versus Electroconvulsive Therapy in DepressionNCT03674671SuspendedPhase 32018-10-29University of Ottawa, Kingston
Study of Ketamine for Depression in Cancer Patients Receiving Palliative CareNCT03410446CompletedPhase 22018-07-16University Health Network, Toronto, Toronto
Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD (Canada)NCT03485287CompletedPhase 22018-03-13Lykos Therapeutics, Vancouver
Ketamine Enhances Analgesia and Mood in Chronic Pain PatientsNCT05985811RecruitingNot reported2018-02-02Salem Anaesthesia Pain Clinic, Surrey
ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant DepressionNCT03272698RecruitingPhase 42017-09-01University of Saskatchewan, Saskatoon
Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major DepressionNCT02924090Status not reportedPhase 42016-09-01University of Manitoba, Winnipeg
Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.NCT02593643CompletedEarly Phase 12016-01-01Sunnybrook Health Sciences Centre, Toronto
Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive TherapyNCT02579642CompletedPhase 42015-10-01University of Alberta, Edmonton
Randomized, Double-blind, Controlled of MDMA-assisted Psychotherapy in 12 Subjects With PTSDNCT01958593TerminatedPhase 22014-10-14Lykos Therapeutics, Vancouver
Action of Ketamine in Treatment-Resistant DepressionNCT01945047CompletedPhase 22013-05-01University of Ottawa, Ottawa

About this data

Compound tags come from automated matching of the registry search term and have not been checked record by record. Counts are of registered studies, not of people, results or approvals. A registry listing is not evidence of safety, benefit or results.

Substance hubs for these compounds

Psilocybin | MDMA | LSD | Ketamine

Institution hubs in this country

Institutions in this country with at least 3 counted studies. The number is that institution's own count of studies, which can include studies not shown above if the registry lists them under another country.

Condition hubs

Condition hubs that include studies counted in this country, with the number of those studies. Conditions are matched by keyword on registered titles, so one study can appear under more than one condition.

Condition hubStudies in this country
Depression44
Treatment-resistant depression26
Bipolar disorder12
Post-traumatic stress disorder10
Cancer and end-of-life distress8
Suicidal ideation and suicide risk8
Alcohol use disorder4
Chronic pain3
Anxiety2
Obsessive-compulsive disorder2
Opioid use disorder1

Other country hubs

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