Ayahuasca clinical trials in the registry
Data as of 10 October 2026. Source: ClinicalTrials.gov records held by PsychoactiveMap, refreshed from a reviewed snapshot.
Ayahuasca is a plant-based brew traditionally prepared in the Amazon basin, usually combining a plant that contains DMT with a plant that contains MAO-inhibiting compounds. This page summarises registered studies whose registry records mention it.
Educational information, not medical advice. A registry listing is not evidence of safety, benefit or results, and it is not a recommendation. PsychoactiveMap does not recruit, screen or refer participants. Status and other details are copied from the registry and can be out of date, so check the registry record and speak to a qualified health professional before any decision. Read the full disclaimer.
At a glance
- 9 registered Ayahuasca studies are counted on this page.
By registry status
| Status | Studies | Share |
|---|---|---|
| Recruiting | 4 | 44% |
| Completed | 4 | 44% |
| Status not reported | 1 | 11% |
By phase
| Phase | Studies | Share |
|---|---|---|
| Early Phase 1 | 1 | 11% |
| Phase 1 | 3 | 33% |
| Phase 2 | 3 | 33% |
| Not applicable | 2 | 22% |
Countries
Country is taken from the study's linked research site. 0 of 9 records have no country on file. The top 3 countries are shown.
| Country | Studies | Share |
|---|---|---|
| Brazil | 6 | 67% |
| Switzerland | 2 | 22% |
| Spain | 1 | 11% |
When studies started
| Start year | Studies |
|---|---|
| 2024 to 2026 | 5 |
| 2020 to 2023 | 3 |
| 2010 to 2014 | 1 |
Study design
- 9 interventional and 0 observational studies.
- Median planned or actual enrolment is 20 participants (range 10 to 84, across 9 records that report it).
Topics named in study titles
A keyword match on registered titles, so one study can appear under more than one topic and a study can be missed. It describes what titles mention, nothing more.
| Topic | Studies |
|---|---|
| Depression and mood | 2 |
| Trauma and PTSD | 1 |
Most recently started studies
The 9 studies with the latest start dates, shown newest first. The order is not a ranking and says nothing about quality. Each ID links to its own ClinicalTrials.gov record, which has the eligibility criteria and contacts.
| Registry ID | Title as registered | Status | Phase | Country | Start |
|---|---|---|---|---|---|
| NCT07747324 | Effects of a Sigle Dose of Ayahuasca in Patients With Psychogenic Non-epileptic Seizures: an Open Label Clinical Trial | Recruiting | Phase 1 | Brazil | 2026-07 |
| NCT07317206 | Ayahuasca, Esketamine and PTSD | Recruiting | Phase 2 | Brazil | 2025-12 |
| NCT07317219 | Ayahuasca, Esketamine and Body Image Perception | Recruiting | Not applicable | Brazil | 2025-12 |
| NCT07317232 | Ayahuasca, Esketamine and Premenstrual Symptoms | Recruiting | Not applicable | Brazil | 2025-12 |
| NCT06252506 | Molecular Imaging Study of Harmine/DMT: a Basic Research Approach | Completed | Phase 1 | Switzerland | 2024-01 |
| NCT05780216 | Mindfulness and Psychedelics | Completed | Early Phase 1 | Switzerland | 2023-02 |
| NCT07212946 | Ayahuasca and Esketamine for Major Depression | Completed | Phase 2 | Brazil | 2022-10 |
| NCT06150859 | Ayahuasca Assisted Psychotherapy for Grief | Status not reported | Phase 2 | Spain | 2021-10 |
| NCT02914769 | Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant Depression | Completed | Phase 1 | Brazil | 2014-02 |
About this data
Compound tags come from automated matching of the registry search term and have not been checked record by record. Counts are of registered studies, not of people, results or approvals.
Other substance hubs
Psilocybin | MDMA | LSD | DMT | 5-MeO-DMT | Ketamine | Ibogaine
Registry status hubs
Recruiting | Not yet recruiting | Active, not recruiting | Enrolling by invitation | Completed | Terminated | Suspended | Withdrawn
Phase hubs
Early Phase 1 | Phase 1 | Phase 2 | Phase 3 | Phase 4 | Phase not applicable